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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8451180af8664b89ae6500a54d36bb10d4b721b016d4fab078c09ebc7e18bfef' 
  AND token = 'RVNwPVmHj+7x1JlfzSTXTTa/HwnW4gyzzA7h7yaNVW0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}