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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21a53645901be4f14dc1f6dc691dac3df94aa09b4e442a8b2b8f5f10115df744' 
  AND token = 'zirDd96cuQhf14qRmDKUvHVGkU057lI1BAgxXB190z8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}