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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '72b7b9b8cb9c64f8e0999c364e31d1cf37b24596491802209bbd8c50d3a0666f' 
  AND token = 'qy8fnzFi9KIHVs4p8JgrDaodCV7ydCxMsMj4kPKeXco=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}