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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '646787cd892beef8bf53630beff80001721e4c024c000cd1f14c912449a8d653' 
  AND token = 'K0RU07W+nKN2IbuYEvF7iwDx4oz3NL85KrIBdXReFQw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}