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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e95f87b801c33b6bf8a58d9a29c2c729d78c2196be579050aff69830f52f2211' 
  AND token = 'T9OVTa1iFuQGIle+9DvVZOvXXYFMLA+OtXFixJKxaCQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}