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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2f748a0c00c8ef6d8228d2d8ef42d19236b1206defd2aac4de6f6448562a8148' 
  AND token = 'JufqHvCWBnV4DYYqMlm4qsaKzj9gsW8xr3Ys0u0oZMU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}