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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '19b05248290cccd44f1f8d8ac91f248a64821333a9779441c3a7bbd14a617c52' 
  AND token = 'Huu94a3ZvXO+90eryBD/0ystUkdsVTVh1RFLKp3qhZo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}