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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9b50404735801a0a4988c2a8bfcb4dcd151b3845b96cf5e3adde792bc1189282' 
  AND token = 'cr+/LBVt90C5Y2X4rSGRfPTh0xI7E4pO1tSFsGAnnq8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}