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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81ec33511b90677c2d4a1fff1a09f5e85d9648d38e2a5108322e60a661312232' 
  AND token = 'FedMtJfx+ykdcL6+57cYeWuvFcD+P1kTZs1OJ4gcBDc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}