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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78a8d4cecd551835b3a0636c23f01f4caf0011422c6d51bfaf73e12c0cc1df4a' 
  AND token = '3ytpa3u4iWKUmJVtt6ERk6XeD7vLRYFVRfkERSuNfSo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}