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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '57b03c357f4b72be5bb97bfb574e6cb0af04e775d53b12405eed2e51e01074a2' 
  AND token = 'pFSCS+dbevoVwRjX9jDcN61uHtpGe4qYHRCsip7jDIA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}