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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '54c8779a9d6c74dc2bad66c5a70d9f397a114d63ad1f32d2bb1b1e8c71874756' 
  AND token = 'IJ5SsNyUSZM8rdRrVKRdgmqNeSlKJQow5iJYZxo9Qq0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}