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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ac9b0596f1c89e3b7fa341ff66b7ab41a13388b1ce3f11814277c31482fe9f49' 
  AND token = '/n51119tPqh62wp4eybHVNIhDSlOBEWOfvAjWoUex1I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}