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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1fa085fab9d7bdc80ecc78f7eb397dc2f62fec075980e36b1e777dd214b72144' 
  AND token = 't5bE2aohHnb3xqUbakXbMDrDPA9P0pwn/+WE9KhFw4k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}