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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '19cf8b78d3d8d3e8da2e242766217f549aa7d22753bc58a170c3c2fba2dd443a' 
  AND token = 'dAC3vL0G/b601Y3giTAL44iwBXr6lheJ3N5Y8Oltahs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}