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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22dd00138e0bc03d39deead287943bfe90e6bcb8f704d178432315a6386315aa' 
  AND token = 'U20H9EF2b7j1zn6PctulKySSf5MKPy9aag6QBOtISyU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}