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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '589c57ea09a2605bb551163daac5a3f6557d743e59a45461fe634d432d71d6bf' 
  AND token = '7fZ7+dEtgazbe96Sf+UMQNy12kG2HtrVQGrAXgsLwBc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}