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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5a03430c130a18c23755c35673437d229706f0952b50a30e8a6e564d4a1ab4f2' 
  AND token = 'GZ5N+3tIXiX/ivj21aUlYu3xs9BUnl0BuWIMl9065Ns=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}