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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '160c104aa99a05dc3fdab208a63c0f6c2718fb5bf75a5b325bf941d77291f942' 
  AND token = 'Z6qkieBDRO3W0C4GGIn8t4rLFOdwipMhKB9GPA6tbDY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}