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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '889e4e423f4c282d56b5aeb5270582da2595e50dc38b2c0de43ee464de41b541' 
  AND token = '2Ajgs7HrmhQG2TDnug3Iu9WiCK+Sqp0b84g06vaxQ5c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}