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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3123b8b08d8534e7e5f15981124f9d6681277fddc994f4ff2a0b055afc287e7d' 
  AND token = 'H3mp4PJBLTOKBWfa9tF6DlsdB1YUEVH0sKtoZOKUgQc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}