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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e1cef7d9a22ce6e32a4550feaded3b3a1ff779f8e90a043e7f3ea68e54e01029' 
  AND token = 'fq0MQXuGEojgX7eq1bDoIDpnqRiKpF7HMNYkVtwt7aE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}