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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5f755aa7800a1b7cd0a4978d8cfe3c61d69be6cd59f3647af62371c3bdedb0ab' 
  AND token = 'ThO00CDTycoRY3/A3ls2Q0M8C24KddbGp2MQ/Ol53YU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}