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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '627904986865e99610f227ae7957f4c59692b5bed5c2df216fbfd60d88b1b1c8' 
  AND token = 'zCvDzr+wKHbiEuCshcSo6WH8do6AuNWmN9nYMoH29yg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}