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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'acd4989c7a9a7e92fd69d7b5623bb9a2e44d26f126dd1b7d4050db58e1335464' 
  AND token = 'vFxJ4UIYe8ondCLDV/6+j5ykdsJSRHLqr1JC8aOfKCU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}