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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e3281af6bfe07a2108b9eb2f53d8976bf3c8a435545591a69b829a8084a63f06' 
  AND token = 'Io2UNcjgIYN6jIitem6K2MerOcMUewTDRRnAd1S01Ms=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}