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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2381a112e6c879011372c9c42e355c797bce7f13f84710fc2d48b6df4522da20' 
  AND token = 'daMgyuLMt/MHKol/UvLyTF4LWNeMLkeXF2jDpOIOoi0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}