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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2e80ac4d0b6cdb203abcbbc28037751f8950071b1aef2729a2ff5c638a8be607' 
  AND token = 'XMYI4wOOWTCFDeBQRG+D4u0fCHhyqqefHHLzzPe/Pq4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}