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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ed85b372b45396c75d7c664e1b74c773a9825cfb68901671a71bf773d61263cf' 
  AND token = 'TqecAz6X5OedYgE3MUjWrjS4sCuNNdFjk5EuSRwL/BY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}