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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65eb00a65dbbdcf3bd999ab5f50173387de8bcaf1c78f103944363c2a8cb1a86' 
  AND token = 'P+YS7yLDGNNtkx5rQOADK2oaoY73Z3+6GQRWa2xxjbM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}