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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '335a3fb6a1d5b0f10453b004f8187b45287a65ccbcc9b31736ea4274f8522b32' 
  AND token = 'cfNM+I6MiMJAp1zzfEilyOz8fbrxPh1XDiG6JCdmghU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}