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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43c458a0eb4b596784e36a4c4952cba56f01d7ec481ea7eac2b9e325f384a211' 
  AND token = 'WMi6iqctcPV0aN/XdJA4VXpKmHFKBddztJj23r0m7FA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}