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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7d66ffafaa3ca1fce6c070eb97872d67375f964cff304f98b54e6223c8a33115' 
  AND token = 'MQuWYO0ECL1fQ35XOld1W8yXVKA+ymtL7y6n/O2uIVg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}