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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ef0e6943b57e0033dd81240080ec3785e8dbde9a0bee3c355e20fc5a07c6b43a' 
  AND token = 'Ceaz5e3mJ6MoblNNSOxbJjzInk8XYvr75WJyc6zcZ4A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}