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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3f4c8c4be2efd25b72df3af9dc2002f0a32b019f0be6df0c9f85d26cc121b910' 
  AND token = 'JEdpinH2kzmc6LS6qAPP23vm+h7s+7YE2D1oL8dtmhM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}