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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '345b1abc33c29274fe2bdd8a37a2239af693e595289d3c03d439e7e461742469' 
  AND token = 'vtMl+sYxA/cio1Yt4xyeA7PTPWcWy+pya43V/FGSj5k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}