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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4556809c787aad3ebdc31da0e85a69ee0b272b0b1ae53078016e5f6be3627367' 
  AND token = 'U6Gs/mKp7OwNaEmJtlNaRzAYM8IJ0chIqGxzctf6v5U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}