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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e356b460b55ddfafce0b302d0f11638af82ea16258ddd55dcb5d160f1ea2570d' 
  AND token = 'De5DsPhQF/SaFtZCIB6SMGWPQgYCVhsHCeNSZoqHAZ4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}