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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ed91e5ce500723d6addf9fe9e831ec39abb2102f283c2e49de614cc56e8f42f7' 
  AND token = 'Av3hHcS0URcyCF/q1xWY4dzqmRpLJMBRJtZu+WN1HyE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}