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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a0bed5821c2e32c4c0a0c383eac2f01279c7d6ff4ad94163993e0a435f760dee' 
  AND token = 'TSuhFQ4Yo/dJnSqqtsMF84nXP3LBsFbS3XiZlPO9fVQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}