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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43176cf69b0766c0b9d0edada33000579a43bbbc5abd01ec0a551ea8e80cc79f' 
  AND token = 'ZiABE/kfoTRX+Rxq5Zo1B24ddSgxwZz9MrCz68jT1MI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}