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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1b3573327f0e9d640c81be455c1fba50c4f16b0e3234b074e22ea9732f2b7428' 
  AND token = 'cYF2AjkghEesv9MEzzSpvFx1DvwNMaGj8HBWj+TjYmw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}