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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '37c8e92497af42f727fc5bb126e61d1d0d23e7e1687b41f78b3a0c387a00ae54' 
  AND token = 'yDYqYBpk0gCQRt7kAZkRUPiyz+hOQ+igz7EdyW/jo8o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}