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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '50e8d1a970a5c12dfacf98c4d6a3372155abcd21f62e0f12781fd6dcb8c85588' 
  AND token = 'Ibqv5/H6UCzb0Fh400NQIFPzxHtfgD+l3FfH+vE464U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}