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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43786116f38df41125b661d2a858fc5a383d0210fb4b2f69c011774b38b9452a' 
  AND token = 'JYJUjV6Bsgbc1aW0B05l+o5BM5M5S9NKghb4Bagi7mA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}