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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd080383ff40b1e9c9a0a20e85b348928e4157bec33435238f8962d4a21f1bded' 
  AND token = 'jVhyiIQf02u3s7i+YoyB1MwH13VA+O9yBGcncwZ6cd0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}