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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3e91e0d51b88cce3e766aadcdc54e3d0a02966621a58ec030d2744f7fad0993c' 
  AND token = 'Xvk32NySXpR+YTCzAnex4Pb1ACoadp3irZaFYYwYkOc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}