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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '044ce3c2f5cdb8c16317de6011ab96df6b7d985f2d2e69abd08c524626468894' 
  AND token = 'NplOPI1a/FgezxEibbDm1U8mPnoiDYG8U9Mj7IcW0D0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}