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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '76801ef383db7e6845e5675d4f5ca7488818c3b3ce8db322d8bb96df3cd306da' 
  AND token = '/wgf25UrGXbZXUVWvPuMrA5Sb5Ck6pWiAemPCMzoWSo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}