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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4b70cb44f3cc988e0d33e9628cbcd6849e71909b5cb4ea6b44da70925086f8b5' 
  AND token = 'UsUsm6iCdQwxzOTDmWZaqZUIqdMJ94c6DR2Gg01mrn0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}